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Gonadotropin-releasing hormone insensitivity : ウィキペディア英語版 | Gonadotropin-releasing hormone insensitivity
Gonadotropin-releasing hormone (GnRH) insensitivity is a rare autosomal recessive genetic and endocrine syndrome which is characterized by inactivating mutations of the gonadotropin-releasing hormone receptor (GnRHR) and thus an insensitivity of the receptor to gonadotropin-releasing hormone (GnRH), resulting in a partial or complete loss of the ability of the gonads to synthesize the sex hormones. The condition manifests itself as isolated hypogonadotropic hypogonadism (IHH), presenting with symptoms such as delayed, reduced, or absent puberty, low or complete lack of libido, and infertility, and is the predominant cause of IHH when it does not present alongside anosmia. ==See also==
* Hypogonadotropic hypogonadism * Kallmann syndrome * Leydig cell hypoplasia * Hypopituitarism * Inborn errors of steroid metabolism * GnRH and gonadotropins * Sex hormones
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Gonadotropin-releasing hormone insensitivity」の詳細全文を読む
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